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Rslogix Emulate 5000 V20.01 (April-2022)




Efficacy and safety of degarelix in the treatment of prostate cancer. Until recently, castration, the mainstay of therapy for prostate cancer, was achieved by surgical or medical castration. However, because of its many side effects, surgical castration was rarely performed, and patients were treated with various regimens of medical castration. Degarelix is a pure gonadotropin-releasing hormone agonist with a long-lasting effect on luteinizing hormone. Its long half-life minimizes the need for frequent injections. In a multicenter, randomized, double-blind, placebo-controlled trial, degarelix, administered subcutaneously at the dose of 200 or 300 mg every 4 weeks, was compared with monthly intramuscular injection of leuprorelin at the dose of 3.75 mg in the treatment of prostate cancer. In this phase 3 study, 145 patients with prostate cancer, whose serum prostate-specific antigen (PSA) levels were greater than 10 ng/mL and were enrolled and treated in 45 centers. Most patients were treated with a single agent and were given the intention-to-treat analysis. The number of patients that had a >or=50% decrease in PSA levels from baseline was significantly greater in the degarelix than in the leuprorelin group (63.1% vs 40.3%, respectively; P =.002). The median time to progression was 55 weeks in the 200-mg degarelix group and 30.5 weeks in the leuprorelin group (P =.008). The median time to progression was 70.2 weeks in the 300-mg degarelix group and 36.5 weeks in the leuprorelin group (P =.01). The median time to progression was 23.1 weeks in the placebo group. The most common adverse events observed were hot flushes (33%), arthralgia (20%), fatigue (18%), and dizziness (14%). Serious adverse events included fractures (4 patients) and testicular atrophy (3 patients). This study showed that degarelix administered subcutaneously every 4 weeks is as effective as and better tolerated than intramuscular injection of leuprorelin, the standard treatment for prostate cancer, and this agent may be effective in patients with the relatively slow-growing disease.Q: How to create first api post request to server? I've created post request to my AngularJS



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Rslogix Emulate 5000 V20.01 (April-2022)

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